DAXXIFY

Daxxify is not just “as good as” BOTOX — in key respects, it outperforms it. Both are FDA-approved botulinum toxin type A products that safely and effectively reduce dynamic wrinkles. The significant difference is duration: BOTOX typically lasts 3 to 4 months, while Daxxify lasts 6 to 9 months in clinical trials. Daxxify also tends to take effect faster (1–5 days vs. 10–14 days for BOTOX). For patients who want longer-lasting results with fewer annual appointments, Daxxify is often the superior choice. 

Like all neurotoxin treatments, Daxxify has some potential side effects. The most common include temporary headache, injection site reactions (redness, bruising, swelling), and eyelid drooping (ptosis) in a small percentage of patients. Because Daxxify is newer, some patients may prefer the longer track record of BOTOX. Cost per session may also be higher — though when factored over the year, total annual spend is often comparable or lower due to fewer treatments needed. 

In Revance’s Phase 3 clinical trials, Daxxify results lasted 6 months in 50% of patients and 9 months in 23% of patients — making it the longest-lasting FDA-approved neurotoxin available. Individual results vary based on metabolism, treatment area, muscle strength, and lifestyle habits. Most patients find they need only 2 treatments per year compared to 3 to 4 with other neurotoxins. 

Ideal candidates are adults with moderate to severe dynamic wrinkles (particularly glabellar lines), who are in good general health and have realistic expectations. Daxxify is especially well-suited to patients who want longer-lasting results, are bothered by frequent injection appointments, or prefer an albumin-free formulation. Pregnant or breastfeeding women and patients with certain neuromuscular conditions are not candidates. 

Daxxify works on dynamic wrinkles — those caused by repeated facial muscle movements. It is highly effective for moderate to severe frown lines, forehead lines, and crow’s feet. For static wrinkles (lines present at rest) or volume loss, dermal fillers or other treatments may be recommended in combination. Your Revive provider will assess your wrinkles and recommend the most effective treatment approach. 

Decades of neurotoxin use is generally considered safe and may even offer long-term benefits. Research and long-term patient observation suggest that consistent neurotoxin use can actually slow the formation of wrinkles over time by reducing the muscle movements that create them. Patients who have used neurotoxins for many years often require lower doses because the treated muscles gradually weaken. There is no evidence that long-term use causes permanent harm or diminishing effectiveness in most patients. 

Both are FDA-approved botulinum toxin type A injectables that temporarily relax facial muscles. Key differences: Duration — Daxxify lasts 6 to 9 months vs. BOTOX’s 3 to 4 months. Onset — Daxxify works in 1 to 5 days vs. BOTOX’s 10 to 14 days. Formulation — Daxxify uses a proprietary peptide technology and contains no albumin; BOTOX uses human serum albumin. Clinical track record — BOTOX has decades of data while Daxxify has 3 years of clinical trial data. Both deliver excellent results in experienced hands. 

For best results and to minimize bruising: avoid blood-thinning medications and supplements (aspirin, ibuprofen, fish oil, vitamin E, alcohol) for at least 3 to 7 days before your appointment if medically safe to do so; arrive with a clean face, free of makeup; stay well-hydrated; and inform your provider of all medications, supplements, and medical conditions. Your Revive provider will give you personalized pre-treatment instructions at your consultation. 

If you discontinue treatments, the effects of Daxxify will gradually wear off as the neurotoxin is metabolized by your body. Your muscles will regain their full movement and the wrinkles they cause will return — though they will not be worse than before you started. Many long-term patients find their skin has improved over years of treatment since consistently reducing muscle movement allows the skin to recover. There are no withdrawal effects associated with stopping neurotoxin treatments. 

Daxxify typically begins to show results within 1 to 5 days of injection — significantly faster than the 10 to 14 days typical of BOTOX and other traditional neurotoxins. This rapid onset makes Daxxify the preferred neurotoxin for patients who need results before a specific event and don’t have 2 weeks to wait. 

Daxxify is FDA-approved specifically for moderate to severe glabellar lines (the “11” lines between the eyebrows). Experienced injectors at Revive may also use it off-label for other areas including horizontal forehead lines, crow’s feet, brow lifting, lip lines, chin dimpling, neck bands, and jaw slimming (masseter reduction). Your provider will recommend the appropriate areas based on your individual anatomy and goals. 

There is generally no significant downtime. Most patients return to their normal activities immediately after treatment. You may experience minor redness, swelling, or bruising at the injection sites, which typically resolves within hours to a few days. We recommend avoiding strenuous exercise, lying flat, and rubbing the treated area for 4 to 6 hours post-treatment. 

The cost of Daxxify treatment at Revive Wellness Centers varies based on the number of units used and the areas being treated. While Daxxify may cost somewhat more per session than traditional neurotoxins, most patients find the overall annual cost is comparable — or even lower — when factoring in the reduced number of treatments required. We encourage you to book a consultation for a personalized quote. We also offer specials and financing options. 

Absolutely. Daxxify works beautifully as part of a comprehensive aesthetic treatment plan. It is commonly combined with dermal fillers (for volume restoration), skin resurfacing treatments such as laser therapy or chemical peels, microneedling, and other in-office procedures. Your Revive provider can design a multi-modality treatment plan that addresses all your aesthetic concerns. 

A Daxxify treatment at Revive is a quick, straightforward in-office procedure. After a consultation, the treatment area is cleansed and your provider uses a very fine needle to administer small injections into the targeted muscles. Most patients describe the sensation as a brief, mild pinch. The entire procedure typically takes 10 to 20 minutes. A topical numbing cream is available upon request. You can drive yourself home and return to most normal activities right away.